THE EFFECT OF LAVOSTATIN FOUND IN MUSHROOM ON LOWELING CHOLESTEROL AND REDUCING RISK OF CARDIOVASCULAR DISEASES-Dr.Kalonga,AE .

THE EFFECT OF LAVOSTATIN FOUND IN MUSHROOM ON LOWELING CHOLESTEROL AND REDUCING RISK OF CARDIOVASCULAR DISEASES-Dr.Kalonga,AE .

 

   Lovastatin is a statin drug, used for lowering cholesterol (hypolipidemic agent) in those with hypercholesterolemia to reduce risk of cardiovascular disease. Lovastatin is a naturally occurring compound found in food such as oyster mushrooms.
     Lovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate.Mevalonate is a required building block for cholesterol biosynthesis and lovastatin interferes with its production by acting as a reversible competitive inhibitor for HMG-CoA, which binds to the HMG-CoA reductase. Lovastatin is a prodrug, an inactive lactone in its native form, the gamma-lactone closed ring form in which it is administered, is hydrolysed in vivo to the β-hydroxy acid open ring form; which is the active form.

Lovastatin and other statins have recently been studied for their chemopreventive and chemotherapeutic effects in certain cancers.
     Oyster mushrooms are a natural source of lovastatin--a chemical used in pharmaceutical drugs to produce expensive drugs such as Mevacor,Advicor,Altocor and Altoprev used to reduce total cholesterol levels in humans. Lovastatin works in the body to inhibit the production of cholesterol, with a special affinity for inhibiting LDL cholesterol.

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